Obesity and the risk of pancreatic cancer

Body Mass Index and Risk, Age of Onset, and Survival in Patients With Pancreatic Cancer. Donghui Li; Jeffrey S. Morris; Jun Liu; Manal M. Hassan; R. Sue Day; Melissa L. Bondy; James L. Abbruzzese. JAMA 2009;301(24):2553-2562

This case-control study by Li and colleagues adds pancreatic cancer to the growing list of cancers,  including of the colon, kidney,  oesophagus, breast (in post-menopausal women) and endometrium, that  are now recognised to be associated with obesity. The study included 841 patients with pancreatic adenocarcinoma and 754 healthy individuals frequency matched by age, race, and sex. Overweight or obesity during early adulthood was associated with a greater risk of pancreatic cancer and a younger age of disease onset. Obesity at an older age was associated with a lower overall survival in patients with pancreatic cancer.