BES 2010: Abstracts from the North West

Adult GH replacement and risk of tumour recurrence: 15 years experience from a large single centre

Scott Mackenzie & Georg Brabant

Christie Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P290

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Circadian and pulsatile secretion of copeptin, an arginine vasopressin (AVP) marker, argues against a physiological role of AVP in cortisol release

Ken Darzy¹, Kashinath Dixit², Stephen Shalet², Nils Morgenthaler³ & Georg Brabant²

¹Department of Endocrinology, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK; ²Department of Endocrinology, Christie Hospital, Manchester, UK; ³Research Department, BRAHMS, AG, Berlin, Germany.

Endocrine Abstracts (2010) 21 P292

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Endocrine outcomes of pituitary surgery

Kate Millar¹, Sanjaya Dissanayake¹, Kaushik Ghosh¹, Nisha Kaimal², David Walmsley², Kalpana Kaushal¹ & Simon Howell¹

¹Royal Preston Hospital, Preston, UK; ²Royal Lancaster Infirmary, Lancaster, UK.

Endocrine Abstracts (2010) 21 P267

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Solitary pituitary metastasis from carcinoma of the prostate: a case report

Seleena Farook, Kanna Gnanalingham, Pyali Pal & Tara Kearney

Royal NHS foundation Trust Manchester, UK.

Endocrine Abstracts (2010) 21 P260

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Long-term unsynchronised transcriptional cycles in individual living pituitary cells

Claire Harper¹, Barbel Finkenstadt², Dan Woodcock², Sonke Friedrichsen³, Sabrina Semprini⁴, Dave Spiller¹, John Mullins⁴, David Rand², Julian Davis³ & Mike White¹

¹University of Liverpool, Liverpool, UK; ²University of Warwick, Coventry, UK; ³University of Manchester, Manchester, UK; ⁴University of Edinburgh, Edinburgh, UK.

Endocrine Abstracts (2010) 21 P293

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Immuno-modulatory role of prolactin in immune tissues driven by the alternative promoter

Anne McNamara¹, Raheela Awais¹, Sabrina Semprini², Claire Harper¹, Karen Featherstone³, Dave Spiller¹, Julian Davis³, John Mullins² & Mike White¹

¹University of Liverpool, Liverpool, UK; ²University of Edinburgh, Edinburgh, UK; ³University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P299

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Adults with partial GH deficiency (GHD) show phenotypic dichotomy related to the timing of onset of the deficiency

Haliza Haniff¹, Judith Adams², Stephen Shalet³ & Robert Murray^1,3

¹Leeds Teaching Hospitals NHS Trust, Leeds, UK; ²University of Manchester, Manchester, UK; ³Christie Hospital NHS Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P301

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The tyrosine phosphatase, SHP-1, acts on multiple tyrosine kinase receptors to negatively regulate human cytotrophoblast proliferation

Karen Forbes, Laura Skinner, John Aplin & Melissa Westwood

University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P316

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Steroid analysis in patients receiving metyrapone therapy

Laura Owen¹, David Halsall², Alexandra Yates¹ & Brian Keevil¹

¹University Hospital of South Manchester, Manchester, UK; ²Addenbrooke’s Hospital, Cambridge, UK.

Endocrine Abstracts (2010) 21 P332

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Reference range data on androsterone glucuronide in healthy male and female volunteers and clinical uses of the assay

Joanne Adaway¹, Adrian Miller¹, F C W Wu² & Brian Keevil¹

¹University Hospital South Manchester NHS Foundation Trust, Manchester, UK; ²Central Manchester and Manchester Childrens University Hospitals NHS Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P333

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Determination of tandem mass spectrometry specific reference ranges for testosterone, androstenedione and DHEAS

Philip Macdonald¹, Frederick Wu², Laura Owen¹ & Brian Keevil¹

¹University Hospital of South Manchester, Manchester, UK; ²Central Manchester and Manchester Children’s University Hospitals, Manchester, UK.

Endocrine Abstracts (2010) 21 P337

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A sensitive and specific tandem mass spectrometry assay for the measurement of salivary testosterone

Philip Macdonald, Laura Owen & Brian Keevil

University Hospital of South Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P338

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Is a raised DHEAS significant when analysed as part of an androgen profile?

Carrie Chadwick¹ & Brian Keevil²

¹Aintree University Hospital Trust, Liverpool, UK; ²South Manchester University Hospital Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P342

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Regulation of glucocorticoid receptor activity by cellular stress

Laura Davies, Malihah Sadeq, Constantinos Demonacos & Marija Krstic-Demonacos

University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P347

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Acute fatty liver due to poor diabetic control

Agnieszka Swiecicka & Manjunath Malige

Royal Bolton Hospital, Bolton, UK.

Endocrine Abstracts (2010) 21 P54

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Severe abdominal pain as presentation of Addison’s disease in undiagnosed case of autoimmune polyglandular disease

Bashir El-Mahmoudi, Tony Tetlow & Chaminda Jayawarna

Tameside General Hospital, Ashton-U-Lyne, Manchester, UK.

Endocrine Abstracts (2010) 21 P31

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Familial GC resistance: a novel, naturally occurring mutation which has dominant negative effects on ligand-dependent and -independent GR action

P Trebble¹, L Matthews¹, J Blaikley¹, A Wayte², G Black¹, A Wilton² & D Ray¹

¹Department of Medicine, University of Manchester, Manchester, UK; ²Department of Medicine and Clinical Biochemistry, Ysbyty Gwynedd, Bangor, UK.

Endocrine Abstracts (2010) 21 OC5.1

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Dicer-dependant microRNAs regulate IGF-actions in the human placenta

Karen Forbes, John Aplin & Melissa Westwood

University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 OC4.5

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The spectrum of disease in diazoxide responsive hyperinsulinaemic hypoglycaemia

Mars Skae¹, Rakesh Amin¹, Leena Patel¹, Helena Gleeson¹, Sarah Ehtisham¹, Mohammed Didi², Jo Blair², Urmi Das², Lindsey Rigby¹, Oliver Blankenstein³, Sian Ellard⁴, Anna Kelsey⁵, Peter Clayton^1,6, Indraneel Banerjee¹ & Catherine Hall¹

¹Department of Paediatric Endocrinology and Diabetes, The New Royal Manchester Children’s Hospital, Manchester, UK; ²Department of Paediatric Endocrinology and Diabetes, Royal Liverpool Children’s Hospital Alder Hey, Liverpool, UK; ³Department of Paediatric Endocrinology and Diabetes, Charite Children’s Hospital, Berlin, Germany; ⁴Peninsula Medical School, Institute of Biomedical and Clinical Science, Exeter, UK; ⁵Department of Histopathology, The New Royal Manchester Children’s Hospital, Manchester, UK; ⁶Endocrine Science Research Group, University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 OC2.7

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Moderate maternal undernutrition results in epigenetic changes in the fetal hypothalamic feeding centres, but not in the fetal HPA axis

Ghazala Begum¹, Adam Stevens¹, Mark Oliver³, Kristin Connor³, John Challis², Frank Bloomfield³ & Anne White¹

¹University of Manchester, Manchester, UK; ²University of Toronto, Toronto, Canada; ³University of Auckland, Auckland, New Zealand.

Endocrine Abstracts (2010) 21 OC1.2

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Mathematical modelling and endocrine research

Julian Davis

Manchester University, Manchester, UK.

Endocrine Abstracts (2010) 21 SB1.3

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Mild primary hyperparathyroidism

Peter Selby

Manchester University, Manchester, UK.

Endocrine Abstracts (2010) 21 CM1.2

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Ubiquitination: the ‘Kiss of Death’ for human growth

Peter E Clayton, Dan Hanson, Philip Murray, Amit Sud & Graeme Black

University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 PL8

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MEN-1 case presentation

Christine Gibson

Manchester Royal Infirmary, Manchester, UK.

Endocrine Abstracts (2010) 21 N1.2

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A psychological aspect of acromegaly

Shashana Shalet

Salford Royal Hospitals NHS Foundation Trust, Salford, UK.

Endocrine Abstracts (2010) 21 N2.3

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A family with functional extraadrenal paragangliomas and positive SDHB gene mutation

Doro Polydorou, Sami Kenz, Daniel Kannapan & Tara Kearney

Salford Royal Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P191

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Weight and glycaemic outcomes following bariatric surgery in people with type 2 diabetes

Yared N Demssie¹, Jhalini Jawaheer¹, Seleena Farook¹, John P New^1,2 & Akheel A Syed^1,2

¹Salford Royal NHS Foundation Trust, Salford, UK; ²University of Manchester, Salford, UK.

Endocrine Abstracts (2010) 21 P161

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Extensive hirsutism, a valuable clue to a sinister pathology

Yared Demssie, Annice Mukherjee, Tara Kearney & Akheel A Syed

Salford Royal NHS Foundation Trust, Salford, UK.

Endocrine Abstracts (2010) 21 P41

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Intra Cerebral Haemorrhage in a young woman with Phaeochromocytoma.

Sami Kenz, Doros Polydorou, Daniel Kanappan, Tara Kearney

Hope Hospital, Salford Royal NHS Foundation Trust. Endocrinology Department, Salford, Manchester M6 8HD

Endocrine Abstracts (2010) 21 P235

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A case of thyroid hormone resistance in a family with three generations of thyroid disease

Doros Polydorou, Daniel Kannapan, Sami Kenz, Angela Paisley & Tara Kearney

Salford Royal Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P396

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Outcome of treatment for patients with acromegaly in a single referral centre

Sanjaya Dissanayake, Kate Millar, Kalpana Kaushal & Simon Howell

Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P258

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Carcinomatous change in a craniopharyngioma: a case report

Simeen Akhtar, Aprajay Golash, Windsor Gunawardena, Andrew Hindley & Simon Howell

Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P257

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Adverse prognosis in breast cancer patients who develop pituitary metastases

Simeen Akhtar, Simon J Howell & Kalpana Kaushal

Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P254

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Is it pituitary adenoma or metastasis?: an unusual presentation of carcinoma prostate

Daniel Kannappan, Sami Kenz, Doros Polydoro, Tara Kearney & Kanna Gnanalingham

Salford Royal Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P248

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Hypopituitarism secondary to pituitary apoplexy- is it due to high dose Aspirin?

Daniel Kannappan, Doros Polydorou, Sami Kenz, Angela Paisley & Tara Kearney

Salford Royal Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P242

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Loss of the Golgi localised E3 ubiquitin ligase containing Cullin 7 in the growth disorder 3-M syndrome leads to reduced cell proliferation and reduced IGF1 mediated activation of Akt

Philip Murray¹, Daniel Hanson¹, Amit Sud¹, Ajibola Omokanye¹, Waqas Khan², Naz Khan³, Kate Chandler³, Mona Aglan⁴, Graeme Black¹ & Peter Clayton¹

¹University of Manchester, Manchester, UK; ²Children’s Hospital Complex, Multan, Pakistan; ³Centran Manchester Foundation Hospitals NHS Trust, Manchester, UK; ⁴National research Centre, Cairo, Egypt.

Endocrine Abstracts (2010) 21 P232

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Altered responses to GH and IGF1 in children born small for gestational age without post-natal catch up growth

Imogen Butcher, Andrew Whatmore, Philip Murray, Melissa Westwood & Peter Clayton

University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P227

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Pro-opiomelanocortin is a novel biomarker for small cell lung cancer

Rachel Stovold¹, Adam Stevens¹, David Ray¹, Paula Sommers¹, Caroline Dive², Fiona Blackhall² & Anne White¹

¹University of Manchester, Manchester, UK; ²Paterson Institute, Manchester, UK.

Endocrine Abstracts (2010) 21 P221

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Investigating the role of HIF-1α in tumour growth and metastasis in an in vivo model of thyroid cancer

Natalie Burrows¹, Julia Resch², Melissa Mejin¹, Georg Brabant² & Kaye Williams¹

¹School of Pharmacy, University of Manchester, Manchester, UK; ²Department of Endocrinology, Christie Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P211

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Impact of adiposity on dynamic changes of serum adipokines after OGTT

Moulinath Banerjee¹, Phillip Pemberton², Valentyn Charlton-Menys¹, William Fraser³ & Kennedy Cruickshank¹

¹Manchester University, Manchester, UK; ²Central Manchester Foundation NHS Trust, Manchester, UK; ³Liverpool University, Liverpool, UK.

Endocrine Abstracts (2010) 21 P122

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Biomarkers of the hypothalamic-pituitary-adrenal (HPA) axis for analysis of in vivo 11β-hydroxysteroid dehydrogenase 1 inhibition

Erika Harno¹, Alice Yu², Brendan Leighton², Andrew Turnbull² & Anne White¹

¹University of Manchester, Manchester, UK; ²CVGI, AstraZeneca, Alderley Park, UK.

Endocrine Abstracts (2010) 21 P171

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Circadian rhythmicity is altered in hepatic corticosterone-related genes from diet induced obese mice

Erika Harno¹, Alice Yu², Henry Brown², Andrew Turnbull², Brendan Leighton² & Anne White¹

¹University of Manchester, Manchester, UK; ²CVGI, AstraZeneca, Alderley Park, UK.

Endocrine Abstracts (2010) 21 P186

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Choroidal malignant melanoma in a patient with Carney complex

Seleena Farook, Christine Gibson & Julian Davis

Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

Endocrine Abstracts (2010) 21 P201

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Peripheral blood mononuclear cells from active rheumatoid arthritis patients show a defective induction of adrenomedullin

Laura Green, Andrew Berry, Rachelle Donn & David Ray

University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P121

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The relationship between electrolyte disturbance and treatment with proton pump inhibitors

Ana Pokrajac & William Stephens

Trafford General Hospital, Manchester, UK.

Endocrine Abstracts (2010) 21 P97

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An evaluation of the knowledge, motivation and weight-management service needs of obese young people

Marc Williams¹, Deborah Kendall², Helena Gleeson², Rakesh Amin², Indi Banerjee², Sarah Ehtisham², Leena Patel², Peter Clayton^2,3 & Catherine Hall²

¹University of Manchester Medical School, Manchester, UK; ²Royal Manchester Children’s Hospital, Manchester, UK; ³University of Manchester, Manchester, UK.

Endocrine Abstracts (2010) 21 P94

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Lithium-induced hypercalcemia and parathyroid dysfunction

Agnieszka Swiecicka & Manjunath Malige

Royal Bolton Hospital, Bolton, UK.

Endocrine Abstracts (2010) 21 P90

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Severe hypomagnesaemia associated with proton pump inhibitor therapy

Sanjaya Dissanayake, Simon Howell, Simon Wallis & Kalpana Kaushal

Royal Preston Hospital, Preston, UK.

Endocrine Abstracts (2010) 21 P83