Canagliflozin and Cardiovascular and Renal Events: NEJM

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

In two trials involving patients with type 2 diabetes and an elevated risk of cardiovascular disease, patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation, primarily at the level of the toe or metatarsal.

doi:10.1056/NEJMoa1611925